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Test Code COL7 Anti-Collagen type VII, IgG Antibodies, Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Secondary ID

616879

Useful For

Initial screening test in the diagnosis of epidermolysis bullosa acquisita and other immunobullous diseases mediated by collagen VII

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Anti-Collagen type VII, Serum

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Clinical Information

Epidermolysis bullosa acquisita and certain other rare immunobullous diseases, including bullous lupus erythematosus, are caused by the development of IgG antibodies directed against collagen type VII, which lead to blisters and erosions that may heal with scarring. Circulating IgG autoantibodies against collagen type VII can be found in patient serum in these conditions.

Reference Values

Collagen type VII

<20 RU/mL (negative)

≥20 RU/mL (positive)

Interpretation

Antibodies to IgG collagen type VII have been shown to be present in patients with epidermolysis bullosa acquisita and certain other rare immunobullous diseases, including bullous lupus erythematosus

CPT Code Information

83516

LOINC Code Information

Test ID Test Order Name Order LOINC Value
COL7 Anti-Collagen type VII, Serum In Process

 

Result ID Test Result Name Result LOINC Value
616879 COL7, S 94096-5