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HelpTest Code IL1B Interleukin-1 Beta, Plasma
Ordering Guidance
If this test is ordered with CYPAN / Cytokine Panel, Plasma, this test will be canceled as duplicate and CYPAN performed as ordered.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Immediately after specimen collection, place tube on wet ice.
2. Centrifuge at 4° C, 1500 x g for 10 minutes.
3. Aliquot plasma into plastic vial.
4. Freeze specimen within 2 hours of collection.
Additional Information:
1. Plasma for this test cannot be shared with other tests. Submit specimen for this test in its own vial.
2. This test cannot be added on to a previously collected specimen.
Secondary ID
622327Useful For
Measuring the concentration of interleukin-1 beta in plasma
Evaluating patients experiencing inflammatory conditions, autoinflammatory disorders, and infection
Method Name
Bead-Based Multiplex Immunoassay
Reporting Name
IL-1 Beta, PSpecimen Type
Plasma EDTASpecimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen | 21 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
| Heat-treated specimen | Reject |
Clinical Information
Interleukin-1 (IL-1) beta is a potent pro-inflammatory cytokine that is crucial for host-defence responses to infection and injury. IL-1 beta binds to IL-1 receptor 1 (IL-1R1) and initiates inflammatory responses in T-lymphocytes, epithelial cells and endothelial cells.(1,2) Excess IL-1 beta signaling have been associated with acute inflammation and chronic autoinflammatory diseases.(3) Plasma IL-1 beta concentrations are elevated in some rheumatoid arthritis patients compared to healthy volunteers. There are increased concentrations of IL-1 beta and tumor necrosis factor-alpha in synovial fluid of rheumatoid arthritis patients.
Several biologics, such as anakinra and canakinumab, have been developed to inhibit the IL-1 signaling pathway by blocking IL-1 beta binding to IL-1 receptors in rheumatoid arthritis, familial Mediterranean fever, cryopyrin-associated periodic syndromes, etc.(2,4)
Reference Values
<18 years: Not established
≥18 years: <20.0 pg/mL
Interpretation
Elevated interleukin-1 beta concentrations could indicate the presence of inflammatory or infectious condition.
CPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IL1B | IL-1 Beta, P | 13629-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 622327 | IL-1 beta | 13629-1 |