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HelpTest Code FMELA Melatonin, Plasma
Specimen Required
***Must submit one specimen per order. Specimens cannot be shared between multiple orders.***
Specimen Type: Plasma
Collection Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Pink top (EDTA)
Submission Container/Tube: Plastic vial
Specimen volume: 3 mL
Collection instructions:
1. Draw blood in EDTA (lavender top) tube(s).
2. Centrifuge and send 1 mL of plasma refrigerated in a plastic vial.
Secondary ID
75386Method Name
High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Melatonin, PlasmaSpecimen Type
Plasma EDTASpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Refrigerated (preferred) | 30 days | |
| Frozen | 365 days | ||
| Ambient | 14 days |
Reject Due To
| Hemolysis | Reject |
| Lipemia | Reject |
| Other reasons for rejection | Polymer gel separation tube (SST or PST) |
Reference Values
Reporting limit determined each analysis.
Units: ng/mL
Interpretation
Endogenous concentrations of melatonin are of the order of less than 0.02-0.2 ng/mL and vary based on time of day and the patient’s age. Single oral doses of 10, 20, 40, and 80 mg given to 20 healthy men resulted in mean peak serum concentrations of approximately 4, 9, 17, and 32 ng/mL, respectively, at 1.3 hours post-dose. Up to 240 mg has been safely administered to adults with side effects that include only drowsiness and sleepiness.Â
CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FMELA | Melatonin, Plasma | 11055-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z3521 | Melatonin | 11055-1 |