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Test Code CDP Celiac Disease Panel

Important Note

Testing includes Tissue Transglutaminase Antibody IgA.

Note that this test is the recommended alternative for Reticulin Antibodies, Serum, which became obsolete in April, 2020.

Specimen Information

Container Specimen Temperature Collect Vol Submit Vol Min Vol Stability
SST Serum Refrigerate 4 mL 1.0 mL 0.6 mL 7 Days

 

Reference Range

If TTAB positive (>10) and IgA normal:
"Celiac disease possible. Consider referral to gastroenterology specialist for consideration for biopsy."

If IgA is age-specific normal and TTAB is equivocal (4-10 U/mL): 
"Equivocal serology, celiac disease cannot be excluded. Referral to gastroenterology specialist recommended for additional evaluation.”
 

If IgA is age specific normal and TTAB is negative (<4.0 U/mL): 
"Negative Serology. Celiac disease unlikely. Approximately 10% of patient with celiac disease are seronegative. Patients who are already adhering to a gluten-free diet may be seronegative. If celiac disease is highly clinically suspected, referral to gastroenterology for additional evaluation is recommended.”
 

If IgA > 6.7 mg/dl, but lower than age-specific normal and TTAB is negative (<10 U/mL): “Low total serum IgA; Recommend referral to gastroenterology specialist for additional evaluation.”
 

If IgA is below detection (< 6.7 mg/dl) and TTAB is negative (<10 U/mL):
“Total serum IgA deficiency; Recommend referral to gastroenterology specialist for additional evaluation.”

CPT / LOINC / Order Code

Meditech Medent LOINC CPT
CDP CDP    
TTA --- 46128-5  
IgA --- 2458-8  
Interpretation --- 69048-7  

 

Test Schedule / Analytic Time / Test Priority

Monday, Thursday / 3 days / Not available STAT

Method

Performed at UVMMC